The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race | 誠品線上

破解基因碼的人: 諾貝爾獎得主珍妮佛．道納、基因編輯, 以及人類的未來

內容簡介

內容簡介 【比爾蓋茲推薦書單：2021年度推薦】紐時暢榜揭開基因編輯密碼基因剪刀 CRISPR的科學革命一出版就空降《紐約時報》暢銷排行榜第1名亞馬遜書店2021年3月選書亞馬遜書店四千多則評價，平均4.7 顆星Goodreads七千多則讀者評價，平均4.4顆星《賈伯斯傳》、《達文西傳》作者最新力作2020年諾貝爾化學獎得主珍妮佛．道納傳記，她的研究足以改變人類歷史！「今年的大獎與生命密碼的改寫有關。這些基因剪刀把生命科學帶入一個新紀元。」──2020年諾貝爾化學獎聲明華特．艾薩克森再次以其生花妙筆，引領讀者進入生物科學界奇才、2020年諾貝爾化學獎得主珍妮佛．道納的世界。這個世界有合作也有競爭，有學術研究也有商業競合，有專利大戰也有科研人的情誼……足以改變人類世界的CRISPR基因編輯技術，不僅充滿基因治療與未來醫學的機會，也饒富各種生物技術應用的商機。基因編輯極可能改變人類歷史，所有人都應該一讀！小學六年級的珍妮佛．道納，有天放學回家時，發現父親在她床上放了一本書名為《雙螺旋》的平裝書。她把書往旁邊一擺，想著這大概又是一本自己熱愛的偵探小說。等到某個下著雨的週六開始看這本書後，她知道，從某個角度來說，自己猜對了。隨著書頁的翻動，書中競相發現生命密碼競賽背後的高潮跌起劇情，讓道納愈發入迷。後來就算她的高中輔導老師告訴她女孩子不會成為科學家，她依然決定朝著科學家之路勇往直前。想要瞭解大自然運作方式的渴望以及希望把發現轉為發明的熱情，一路驅使道納向前走，並邁入了《雙螺旋》作者詹姆斯．華生所告訴她的，繼他與其他人共同發現DNA結構之後的最重要生物學進程當中。她與合作者將自然界的一個奇特現象，改造成了一項可以改變人類的發明──可以編輯DNA的簡易工具。被眾人稱為CRISPR的這項工具，開啟了一個帶來醫藥奇蹟的美麗新世界，但同時也引發了諸多道德問題。在CRISPR的研發過程中，道納與共同獲得諾貝爾獎的夏彭蒂耶之間的友誼和競合關係、道納與其研究室夥伴的相互支持、道納與其他研究CRISPR科學家間的論文發表時間賽跑……，各種人性的考驗與科學家間的良性與惡性競爭逐漸浮上檯面，也造成了日後的專利大戰、生技公司商業競爭、基因編輯寶寶的道德議題，這究竟是生物科學之幸或不幸？協助發現了基因剪刀後，道納成了道德議題角力的主導人物之一，同時也在2020年與她的合作夥伴埃瑪紐埃爾．夏彭蒂耶共同榮獲諾貝爾化學獎。新冠疫情蔓延全球，於是CRISPR被迅速轉為應用來抵禦病毒、研發疫苗，道納也肩負起領頭羊的責任，召集相關研究科學家，大家摒棄成見，並肩合作，共享智慧財產權，一起為抗疫努力！CRISPR的發展以及與新冠病毒賽跑，希望創製出疫苗的努力，必然會縮短我們進入下一個偉大創新革命的過渡時期。過去半個世紀一直是奠基於微晶片、電腦與網路的數位時代。現在，我們正要跨入一個生命科學的革命風暴。學習數位編碼的孩子身邊，很快將有學習基因編碼的孩子並肩前行。珍妮佛．道納的故事有如一則扣人心弦的偵探故事，故事中有著從生命起源到人類物種未來的最深奧自然驚奇。本中文書介出自《破解基因碼的人: 諾貝爾獎得主珍妮佛．道納、基因編輯, 以及人類的未來》商周出版The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species."

作者介紹

作者介紹 Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.

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